Current Issue : July-September Volume : 2014 Issue Number : 3 Articles : 10 Articles
The effects of Cardiospermum Halicacabum leaf extracts on different phases of acute inflammation were examined. Investigations were performed using different phlogistic agents-induced paw oedema viz., Carrageenan-induced paw oedema and Dextran- induced paw oedema in rats. Various extracts (ethanol and aqueous) of Cardiospermum Halicacabum leaf at a dose of 250 mg/kg and 500 mg/kg orally were tested. Diclofenac sodium at the dose of 10mg/kg was used as standard. Both the extracts showed significant activity (*p<0.05 & **p<0.01) compared with the control in both of these models. The dry powdered seeds were found to contain alkaloids, glycosides, saponins, tannins and carbohydrates. Thus it is revealed from the screening model used that the ethanol extract and aqueous fraction of this plant possesses acute anti-inflammatory activity....
Objectives: Jatropha gossypifolia linn. (Euphorbiaceae) is an important and widely used medicinal plant. Jatropha gossypifolia is used as a traditional folk medicine in ailments such as inflammation, arthritis, wounds, antioxidants, tumors and burns, degenerative joint disease, urinary calculi, anticoagulants, amenorrhea and dysmenorrhea. \r\nKey finding: The total flavonoid content of ethanolic leaf extract of Jatropha gossypifolia was determined by using aluminium chloride colorimetric method. Flavonoid compounds were found to be 10.29 �µg of quercetin equivalent [QE] per mg of ethanolic leaves extract of Jatropha gossypifolia which is comparatively less to the aqueous leaves extract of Jatropha gossypifolia. Conclusion: In this study phytochemical analysis of ethanolic extract of J. gossypifolia L. has indicated the presence of flavonoid, glycoside, steroids, saponins and alkaloids. Since these compounds are of pharmacological interest, coupled with the use of this plant in traditional medicine....
To investigate the antihyperglycemic and antioxidant properties of the petroleum ether extract of Platycladus orientalis leaves in streptozotocin-induced diabetic rats, hyperglycemia was induced in rats by streptozotocin (STZ, 45 mg/kg body weight). Three days after STZ induction, diabetic rats received Platycladus extract at 100 and 200 mg/kg body weight daily for 28 days. Glibenclamide (600 µgm/kg) served as reference. Blood glucose levels were measured on every 7th day during 28 days. Serum biochemical parameters low density lipoprotein (LDL), very low density lipoprotein (VLDL), high density lipoprotein (HDL), atherogenic index and the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP)were estimated. Antioxidant enzymes (catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH), serum thiobarbituric (TBAR) was measured in the diabetic rats. Therefore, Platycladus orientalis demonstrated remarkable antidiabetic activity in STZ induced diabetic rats. The potential antidiabetic action is plausibly due to its modulation of endogenous antioxidant status. Administration of the extracts for 28 days caused a significant (P<0.01) reduction in blood glucose levels in diabetic mice. The extracts also improved other altered biochemical parameters associated with diabetes. Furthermore, the extracts have favorable effects on the histopathological changes of the pancreas, in STZ induced diabetic mice. The extracts also showed significant (P<0.05) antioxidant activity. Platycladus orientalis possesses antihyperglycemic and antioxidant properties as well improved lipid profile....
The plant Pergularia daemia has been traditionally used for treating various diseases. The present study was aimed to investigate the anti-inflammatory activity of aqueous extract of the whole plant of Pergularia daemia by human red blood cell (HRBC) membrane stabilization method. The prevention of hypo tonicity induced human red blood cells (HRBC) membrane lysis was taken as a measure of the anti-inflammatory activity. Phytochemical assay was done to find the main active constituents. Among all the concentrations 400 μg/ml showed significant anti-inflammatory activity and 78.97% protection and the standard drug diclofenac showed 86.68% protection. IC50 values were calculated and found to be 217 μg/ml and 200µg/ml for plant extract and standard diclofenac respectively. The results obtained in the present study suggest that Pergularia daemia can be a potential source of anti-inflammatory agents....
The plant Pergularia daemia has been traditionally used for treating various diseases. The present study was aimed to investigate the anti-inflammatory activity of aqueous extract of the whole plant of Pergularia daemia by heat induced haemolysis stabilization method. The prevention of hypo tonicity induced heat induced haemolysis was taken as a measure of the anti-inflammatory activity. Phyto chemical assay was done to find the main active constituents. Among all the concentrations 400 μg/ml showed significant anti-inflammatory activity and 73.49% protection and the standard drug diclofenac showed 62.09% protection. IC50 values were calculated and found to be 150 μg/ml and 200 µg/ml for plant extract and standard diclofenac respectively. The results obtained in the present study suggest that Pergularia daemia can be a potential source of anti-inflammatory agents....
Brassica oleracea commonly called as cabbage is a good vegetative source. It has been reported to have high antioxidant properties due to the presence various phytoconstituents. Extraction procedure was done by maceration process using aqueous methanol (20:80) as solvent and acute toxicity studies, phytochemical screening were carried out using standard procedures. In vitro antioxidant studies were conducted using DPPH method. For the present study, reserpine model was selected for parkinsonian disease. Reserpine is administered at a dose of 5mg/kg i.p., for 5 consecutive days. Behavioral parameters, biochemical parameters and histopathological changes were estimated. The groups treated with hydroalcoholic extract of Brassica oleracea (250 & 500mg/kg p.o.,) showed increased locomotor activity, motor coordination, SOD, CAT, GSH levels were as the cataleptic behavior and LPO was decreased when compared to negative control group. Histopathology also showed normal cerebellum. The pharmacological screening revealed that the plant extract shown dose dependent action. These results suggest the involvement of antioxidant activity in treating reserpine induced parkinsonian disease. It also confirms that the hydroalcoholic extract of Brassica oleracea (HABO) is having antioxidant activity which may be due to the presence of phytoconstituents like flavonoids. This study predicts the scope of Brassica oleracea in the possible treatment of neuroleptic-induced Parkinsonian Disease....
The aim of the present study is to evaluate the antipyretic activity of ethanolic extract of Canthium Dicoccum using yeast induced pyrexia in albino rats. Canthium Dicoccum belonging to family Rubiaceae commonly known as Nallamandharam in India is a branched glabrous shrub or small trees. The various plant parts like stem bark, roots, flowers and seeds have also been used in traditional medicine. The results of the statistical analysis showed that the ethanolic extract of Canthium Dicoccum had significant (p<0.05) dose dependent antipyretic properties at 200 and 400mg/kg on pyrexia induced by yeast on albino rats. The present investigation revealed that the ethanolic extract of Canthium Dicoccum possess a very good anti pyretic activity....
Hedychium coronarium J Koeing belonging to family zingiberaceae is a widely used medicinal plant for treatment of various life style related disorders. The rhizomes of this plant have been widely used in the treatment as well as management of various disorders. In the present study, aqueous and ethanolic extracts of the rhizomes were subjected to in-vitro antioxidant activity screening models such as DPPH, ABTS, nitric oxide and superoxide radical scavenging activity, inhibition of lipid peroxidation, reduction of ferric ions and total antioxidant capacity. Ascorbic acid was used as the standard. In all the models studied, both the extracts showed nearly equal activities thereby augmenting the plant into the present day systems of medicine....
With the steady increase in the number of people suffering from diabetes and due to untoward effect of present synthetic oral antidiabetic drugs, search for new hypoglycemic drugs from natural source is going on. The present study aimed at evaluation of anti-hyperglycemic potential of two traditionally used plants - Marsdenia tenacissima, Sphaeranthus indicus, by in vitro methods. Both the plants possess hypoglycemic activity though the activity was more in Marsdenia tenacisima. The results of the study revealed that the hypoglycemic activity is more prominent in neutral and basic media as compared to acidic medium....
The current study is designed to evaluate the presence of steroid in commonly used unregistered aphrodisiac and anti-arthritic herbal formulation because in unregistered herbal medicines steroids are added deliberately to achieve magical therapeutic effects. It has been seen that, due to lack of quality control, the drugs which are indicated on the container of the herbal medicines are actually not added in these unregistered formulations. Although this work is done on preliminary level, but this work will open the doors for the researchers to evaluate unregistered herbal formulations for the presence of phyto steroids or steroids which are added in formulation for rapid therapeutic effects....
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